HitPredict

Interactor 1: PAXI (P49023)
Paxillin
Gene: PXN

Interactor 2: PARVA (Q9NVD7)
Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2)
Gene: PARVA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.657

Property	Details
Experiments	18508764, 18940607, 11134073
Identification Methods	x-ray crystallography, classical fluorescence spectroscopy, nuclear magnetic resonance, anti bait coimmunoprecipitation
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0030027 - lamellipodium GO:0034446 - substrate adhesion-dependent cell spreading
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 372
+	Hs
		238995 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		PARVA_HUMAN (1-372): 0: 571: 100.00
+	Hs
		816288 LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97		PARVA_HUMAN (1-372): 0: 571: 100.00
+	Hs
		1190450 LIMS2_HUMAN (346-529): 5.39e-43: 158: 34.05		PARVA_HUMAN (1-372): 0: 571: 100.00
+	Mm
		1307770 LIMS1_MOUSE (346-529): 2.18e-43: 159: 32.97		PARVA_MOUSE (1-372): 0: 569: 98.39
+	Hs
		816281 LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97		PARVB_HUMAN (23-372): 0: 551: 75.71
+	Dm
		1213626 Q8INQ9_DROME (347-529): 4.38e-40: 151: 31.61		Q9VWD0_DROME (12-370): 0: 519: 57.78
+	Hs
		816280 LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97		PARVG_HUMAN (69-368): 1.36e-145: 417: 43.00
+	Hs
		1204926 ZN677_HUMAN (205-475): 3.21e-37: 148: 9.24		PARVG_HUMAN (69-368): 1.36e-145: 417: 43.00
+	Hs
		1335458 PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90		PARVG_HUMAN (69-368): 1.36e-145: 417: 43.00
+	Ce
		184095 UNC97_CAEEL (344-438): 1.43e-09: 61.9: 22.92		PARV_CAEEL (13-371): 2.2e-151: 433: 46.28