HitPredict

Interactor 1: NR2C2 (P49116)
Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
Gene: NR2C2

Interactor 2: FOXL1 (Q12952)
Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)
Gene: FOXL1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25609649
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity GO:0030154 - cell differentiation and 1 others more... GO:0043565 - sequence-specific DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 596 Hs			1 345
+	Hs
		525302 NR2C1_HUMAN (21-596): 1.19e-132: 402: 60.50		FOXL2_HUMAN (40-138): 8.25e-50: 172: 66.67
+	Mm
		291652 NR2C1_MOUSE (21-596): 2.59e-130: 395: 60.03		FOXL2_MOUSE (29-138): 1.71e-48: 168: 60.00
+	Hs
		490099 COT1_HUMAN (47-193): 9.02e-48: 174: 41.45		FOXL1_HUMAN (1-345): 1.46e-108: 322: 100.00
+	Dm
		970522 HR78_DROME (82-580): 1.38e-77: 259: 25.39		FD3_DROME (46-157): 6.07e-55: 187: 58.93
+	Dm
		685380 HR78_DROME (82-580): 1.38e-77: 259: 25.39		FD5_DROME (38-254): 3.07e-56: 185: 33.95
+	Ce
		106959 NH114_CAEEL (103-580): 1.75e-77: 253: 16.42		PHA4_CAEEL (13-275): 2.49e-55: 190: 29.41
+	Ce
		999481 NHR22_CAEEL (50-583): 2.54e-75: 252: 15.64		PHA4_CAEEL (13-275): 2.49e-55: 190: 29.41
+	Dm
		685354 HR78_DROME (82-580): 1.38e-77: 259: 25.39		CROC_DROME (30-148): 2.28e-50: 176: 63.03
+	Dm
		539752 HR78_DROME (82-580): 1.38e-77: 259: 25.39		FKH_DROME (13-178): 4.86e-49: 173: 42.77
+	Hs
		622779 COT2_HUMAN (106-277): 8.49e-46: 168: 40.33		FOXA1_HUMAN (5-320): 1.41e-80: 255: 30.27
+	Ce
		220329 NHR49_CAEEL (115-582): 7.87e-66: 225: 21.19		PHA4_CAEEL (13-275): 2.49e-55: 190: 29.41
+	Dm
		685393 HR78_DROME (82-580): 1.38e-77: 259: 25.39		SLP2_DROME (48-144): 4.31e-28: 115: 61.86
+	Hs
		487931 RARA_HUMAN (66-191): 1.29e-27: 118: 44.53		FOXA1_HUMAN (5-320): 1.41e-80: 255: 30.27
+	Hs
		782535 HNF4A_HUMAN (88-274): 1.46e-51: 186: 33.85		FOXC1_HUMAN (9-280): 1.15e-53: 186: 35.86
+	Hs
		782521 HNF4A_HUMAN (88-274): 1.46e-51: 186: 33.85		FOXK2_HUMAN (1-245): 2.81e-51: 182: 32.45
+	Hs
		490091 COT1_HUMAN (47-193): 9.02e-48: 174: 41.45		FOXG1_HUMAN (48-224): 2.13e-52: 182: 40.68
+	Hs
		490113 COT1_HUMAN (47-193): 9.02e-48: 174: 41.45		FOXC2_HUMAN (11-301): 4.93e-52: 181: 32.48
+	Hs
		490092 COT1_HUMAN (47-193): 9.02e-48: 174: 41.45		FOXA3_HUMAN (47-146): 1.57e-50: 173: 63.00
+	Hs
		208887 COT1_HUMAN (47-193): 9.02e-48: 174: 41.45		FOXS1_HUMAN (38-240): 7.82e-49: 168: 41.38
+	Ce
		1088830 Q7KX66_CAEEL (117-220): 4.74e-25: 105: 40.95		PHA4_CAEEL (13-275): 2.49e-55: 190: 29.41