HitPredict

Interactor 1: NR2C2 (P49116)
Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
Gene: NR2C2

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30463901
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 596 Hs			1 488
+	Hs
		823977 NR2C2_HUMAN (1-596): 0: 527: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		525327 NR2C1_HUMAN (21-596): 1.19e-132: 402: 60.50		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		177232 NR2C2_HUMAN (1-596): 0: 527: 100.00		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		525310 NR2C1_HUMAN (21-596): 1.19e-132: 402: 60.50		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177183 NR2C1_HUMAN (21-596): 1.19e-132: 402: 60.50		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		1038387 NR1D2_HUMAN (89-566): 4.51e-92: 296: 18.59		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1030585 STF1_HUMAN (110-583): 1.35e-87: 281: 21.47		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		846410 RORG_HUMAN (94-584): 2.21e-86: 280: 20.81		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		1096252 HR78_DROME (82-580): 1.38e-77: 259: 25.39		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		1270541 NR2E1_HUMAN (116-324): 6.69e-47: 171: 29.28		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		140236 RXRA_MOUSE (16-291): 4.35e-62: 214: 26.83		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		177193 NR1D1_HUMAN (23-566): 1.48e-87: 285: 18.64		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		292408 RORA_MOUSE (60-583): 2.49e-88: 285: 20.83		HDAC3_MOUSE (10-431): 0: 574: 58.49
+	Hs
		1038843 NR2E1_HUMAN (116-324): 6.69e-47: 171: 29.28		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		622790 COT2_HUMAN (106-277): 8.49e-46: 168: 40.33		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177191 RXRA_HUMAN (1-291): 9.13e-62: 213: 26.82		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		177223 HNF4A_HUMAN (88-274): 1.46e-51: 186: 33.85		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		177412 NR2E1_HUMAN (116-324): 6.69e-47: 171: 29.28		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		292417 NR2E1_MOUSE (116-324): 1.31e-46: 170: 29.28		HDAC3_MOUSE (10-431): 0: 574: 58.49
+	Hs
		1260206 NR2E1_HUMAN (116-324): 6.69e-47: 171: 29.28		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37