HitPredict

Interactor 1: ERCC3 (P49135)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH 89 kDa subunit) (Xeroderma pigmentosum group B-complementing protein)
Gene: ERCC3

Interactor 2: SMAD1 (P70340)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
Gene: SMAD1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16101586
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006366 - transcription by RNA polymerase II
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 783 Mm			1 465
+	Mm
		824610 ERCC3_MOUSE (1-783): 0: 705: 100.00		SMAD5_MOUSE (2-465): 0: 616: 89.03
+	Mm
		824614 ERCC3_MOUSE (1-783): 0: 705: 100.00		SMAD9_MOUSE (3-465): 0: 575: 76.51
+	Hs
		584603 ERCC3_HUMAN (1-783): 0: 701: 95.79		SMAD2_HUMAN (3-465): 0: 537: 55.14
+	Mm
		936615 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD1_MOUSE (1-465): 0: 654: 100.00
+	Hs
		571470 DDX5_HUMAN (234-756): 1.25e-105: 338: 12.09		SMAD1_HUMAN (1-465): 0: 653: 99.14
+	Hs
		571568 DDX5_HUMAN (234-756): 1.25e-105: 338: 12.09		SMAD5_HUMAN (2-465): 0: 618: 89.25
+	Mm
		1207259 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD3_MOUSE (3-465): 0: 554: 59.44
+	Hs
		571401 DDX5_HUMAN (234-756): 1.25e-105: 338: 12.09		SMAD3_HUMAN (3-465): 0: 554: 59.44
+	Hs
		133977 DDX3X_HUMAN (202-678): 1.71e-100: 326: 11.11		SMAD3_HUMAN (3-465): 0: 554: 59.44
+	Mm
		1143947 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD2_MOUSE (3-465): 0: 539: 55.14
+	Hs
		181693 DDX3Y_HUMAN (192-678): 1.2e-98: 321: 11.30		SMAD3_HUMAN (3-465): 0: 554: 59.44
+	Hs
		181701 DDX3Y_HUMAN (192-678): 1.2e-98: 321: 11.30		SMAD2_HUMAN (3-465): 0: 537: 55.14
+	Mm
		956548 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD4_MOUSE (8-454): 6.82e-151: 442: 33.33
+	Mm
		192488 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD7_MOUSE (30-131): 1.02e-24: 107: 33.33