HitPredict

Interactor 1: MAPK2 (P49137)
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)
Gene: MAPKAPK2

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	12861023
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 245
+	At
		965291 CDPK1_ARATH (6-398): 5.66e-135: 401: 27.52		14332_ARATH (3-239): 6.89e-143: 401: 65.15
+	At
		802001 CDPK1_ARATH (6-398): 5.66e-135: 401: 27.52		14334_ARATH (3-239): 1.97e-140: 396: 63.07
+	Mm
		926819 KCC2D_MOUSE (57-394): 2.72e-119: 357: 33.05		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Hs
		909532 KCC2D_HUMAN (57-394): 2.72e-119: 357: 33.05		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		927272 MAPK5_HUMAN (54-387): 1.43e-85: 270: 42.50		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		904532 KCC2D_HUMAN (57-394): 2.72e-119: 357: 33.05		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		647086 MAPK5_HUMAN (54-387): 1.43e-85: 270: 42.50		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		684020 KCC2D_HUMAN (57-394): 2.72e-119: 357: 33.05		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		904824 MAPK5_HUMAN (54-387): 1.43e-85: 270: 42.50		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		270395 KS6A5_HUMAN (68-314): 6.25e-23: 103: 32.83		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		909590 KS6A2_HUMAN (47-326): 1.48e-22: 101: 28.19		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646741 KS6A3_HUMAN (68-314): 7.5e-22: 99.8: 29.73		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683216 KS6A3_HUMAN (68-314): 7.5e-22: 99.8: 29.73		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		646913 KS6A1_HUMAN (68-314): 4.72e-20: 94.4: 29.07		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683368 KS6A1_HUMAN (68-314): 4.72e-20: 94.4: 29.07		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		850630 KS6A3_HUMAN (68-314): 7.5e-22: 99.8: 29.73		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		850642 KS6A3_HUMAN (68-314): 7.5e-22: 99.8: 29.73		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		904590 KS6A1_HUMAN (68-314): 4.72e-20: 94.4: 29.07		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982035 KS6A1_HUMAN (68-314): 4.72e-20: 94.4: 29.07		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		684052 KS6A2_HUMAN (47-326): 1.48e-22: 101: 28.19		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97