HitPredict

Interactor 1: MAPK2 (P49137)
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)
Gene: MAPKAPK2

Interactor 2: MAPK3 (Q16644)
MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)
Gene: MAPKAPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 33961781, 32707033
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0002224 - toll-like receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
and 13 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 400
Hs

1 382
+ At
+ At
+ At
+ Gm
+ At
+ Hs
+ Mm
+ At
+ Hs
+ At
+ At
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs

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Last updated: 15 Jul 2024