HitPredict

Interactor 1: CDK8 (P49336)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Gene: CDK8

Interactor 2: MD13L (Q71F56)
Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
Gene: MED13L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	24981860, 26186194, 26496610, 28514442, 29568061, 33961781, 32707033, 23602568, unassigned1655
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016592 - mediator complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 464 Hs			1 2210
+	Hs
		1174776 CDK19_HUMAN (1-464): 1.35e-144: 424: 75.90		MD13L_HUMAN (1-2210): 0: 3763: 100.00
+	Hs
		73031 B4DUB1_HUMAN (152-464): 5.46e-111: 334: 69.52		MD13L_HUMAN (1-2210): 0: 3763: 100.00
+	Mm
		1131974 CDK8_MOUSE (1-464): 8.68e-171: 489: 98.92		MED13_MOUSE (4-2210): 0: 3229: 51.97
+	Hs
		826370 CDK8_HUMAN (1-464): 6.01e-167: 480: 100.00		MED13_HUMAN (4-2210): 0: 3181: 51.34
+	Hs
		1314888 CDK19_HUMAN (1-464): 1.35e-144: 424: 75.90		MED13_HUMAN (4-2210): 0: 3181: 51.34
+	Hs
		73048 B4DUB1_HUMAN (152-464): 5.46e-111: 334: 69.52		MED13_HUMAN (4-2210): 0: 3181: 51.34
+	Dm
		1182305 CDK8_DROME (1-372): 8.32e-138: 405: 84.68		MED13_DROME (943-1152): 8.63e-10: 66.7: 23.77