HitPredict

Interactor 1: CDK8 (P49336)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Gene: CDK8

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11867769
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 464 Hs			1 530
+	Hs
		369182 CDK8_HUMAN (1-464): 6.01e-167: 480: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269520 CDK19_HUMAN (1-464): 1.35e-144: 424: 75.90		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Mm
		1142696 CDK8_MOUSE (1-464): 8.68e-171: 489: 98.92		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		647642 MK03_HUMAN (9-384): 9.15e-118: 351: 30.63		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369006 CDK2_HUMAN (17-343): 2.28e-135: 393: 35.05		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368820 CDK1_HUMAN (19-338): 6.33e-121: 356: 35.49		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369038 MK01_HUMAN (11-373): 1.1e-117: 350: 29.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		414730 CDK1_HUMAN (19-338): 6.33e-121: 356: 35.49		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		587119 MK03_HUMAN (9-384): 9.15e-118: 351: 30.63		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		587121 MK01_HUMAN (11-373): 1.1e-117: 350: 29.00		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		647494 MK03_HUMAN (9-384): 9.15e-118: 351: 30.63		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		658827 MK01_HUMAN (11-373): 1.1e-117: 350: 29.00		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		487905 MK01_HUMAN (11-373): 1.1e-117: 350: 29.00		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		647499 MK03_HUMAN (9-384): 9.15e-118: 351: 30.63		NR4A2_HUMAN (23-501): 3.24e-98: 311: 23.30
+	Hs
		658834 MK01_HUMAN (11-373): 1.1e-117: 350: 29.00		NR4A2_HUMAN (23-501): 3.24e-98: 311: 23.30
+	Hs
		487228 CDK8_HUMAN (1-464): 6.01e-167: 480: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		414440 CDK2_HUMAN (17-343): 2.28e-135: 393: 35.05		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		414445 MK01_HUMAN (11-373): 1.1e-117: 350: 29.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		414697 CDK1_HUMAN (19-338): 6.33e-121: 356: 35.49		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487159 MK01_HUMAN (11-373): 1.1e-117: 350: 29.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59