HitPredict

Interactor 1: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Interactor 2: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12065593
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 352
+	Hs
		674834 ARRB1_HUMAN (1-418): 0: 716: 100.00		AGTR1_HUMAN (5-348): 4.25e-71: 227: 28.98
+	Hs
		781016 ARRB1_HUMAN (1-418): 0: 716: 100.00		OPRD_HUMAN (14-351): 8.73e-69: 221: 22.25
+	Rn
		626613 ARRB1_RAT (1-418): 0: 707: 99.04		AGTRA_RAT (5-349): 1.86e-71: 228: 28.41
+	Mm
		669680 ARRB1_MOUSE (1-418): 0: 703: 98.57		AGTRA_MOUSE (5-349): 3.15e-71: 227: 27.84
+	Hs
		625750 ARRB1_HUMAN (1-418): 0: 716: 100.00		CXCR2_HUMAN (17-315): 2.57e-44: 157: 34.55
+	Hs
		626815 ARRB1_HUMAN (1-418): 0: 716: 100.00		ACKR3_HUMAN (20-318): 5.63e-38: 140: 27.54
+	Hs
		674827 ARRB2_HUMAN (1-407): 0: 626: 76.15		AGTR1_HUMAN (5-348): 4.25e-71: 227: 28.98
+	Hs
		428933 ARRB2_HUMAN (1-407): 0: 626: 76.15		ADRB2_HUMAN (3-336): 5.8e-69: 223: 17.52
+	Hs
		685822 ARRB2_HUMAN (1-407): 0: 626: 76.15		OPRD_HUMAN (14-351): 8.73e-69: 221: 22.25
+	Rn
		626614 ARRB2_RAT (1-407): 0: 616: 75.00		AGTRA_RAT (5-349): 1.86e-71: 228: 28.41
+	Rn
		663954 ARRB2_RAT (1-407): 0: 616: 75.00		Q8VBU7_RAT (1-334): 2.96e-70: 227: 18.01
+	Hs
		685813 ARRB2_HUMAN (1-407): 0: 626: 76.15		APJ_HUMAN (4-339): 7.08e-67: 217: 22.22