HitPredict

Interactor 1: B9EKI5 (B9EKI5)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
Gene: Cblb

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 938 Mm			1 217
+	Mm
		1112053 CBLB_MOUSE (1-938): 0: 902: 94.20		GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00
+	Mm
		82734 B9EKI5_MOUSE (1-938): 0: 926: 100.00		LYN_MOUSE (3-202): 3.06e-38: 140: 27.49
+	Mm
		411924 CBLB_MOUSE (1-938): 0: 902: 94.20		LCK_MOUSE (3-202): 5.14e-38: 139: 28.44
+	Mm
		82738 B9EKI5_MOUSE (1-938): 0: 926: 100.00		NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14
+	Hs
		411703 CBLB_HUMAN (1-938): 0: 875: 88.91		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Mm
		782847 CBLB_MOUSE (1-938): 0: 902: 94.20		CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57
+	Mm
		82736 B9EKI5_MOUSE (1-938): 0: 926: 100.00		VAV2_MOUSE (3-56): 6.98e-11: 63.1: 40.00
+	Rn
		1144046 CBLB_RAT (1-938): 0: 919: 98.40		FYN_RAT (161-215): 4.88e-13: 69.2: 31.58
+	Mm
		1112081 CBLB_MOUSE (1-938): 0: 902: 94.20		ITSN2_MOUSE (2-61): 1.71e-14: 73.8: 35.00
+	Hs
		557678 CBLB_HUMAN (1-938): 0: 875: 88.91		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337458 CBLB_HUMAN (1-938): 0: 875: 88.91		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		69208 CBLB_HUMAN (1-938): 0: 875: 88.91		A9UF07_HUMAN (4-139): 1.72e-21: 94: 35.46
+	Mm
		1112072 CBLB_MOUSE (1-938): 0: 902: 94.20		GRAP_MOUSE (3-57): 4.79e-12: 64.6: 34.55
+	Mm
		292684 CBLB_MOUSE (1-938): 0: 902: 94.20		GRAP2_MOUSE (3-55): 1.77e-10: 61.1: 37.74
+	Hs
		548699 CBLB_HUMAN (1-938): 0: 875: 88.91		VAV_HUMAN (3-60): 1.14e-15: 76.9: 43.10
+	Hs
		412170 CBLB_HUMAN (1-938): 0: 875: 88.91		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		433339 CBLB_HUMAN (1-938): 0: 875: 88.91		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		855791 CBLB_HUMAN (1-938): 0: 875: 88.91		VAV2_HUMAN (3-56): 6.02e-11: 63.1: 38.18
+	Hs
		275194 CBLB_HUMAN (1-938): 0: 875: 88.91		GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62
+	Hs
		522956 CBLB_HUMAN (1-938): 0: 875: 88.91		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03