HitPredict

Interactor 1: B9EKI5 (B9EKI5)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
Gene: Cblb

Interactor 2: NCK1 (Q99M51)
SH2/SH3 adapter protein Nck1 (Cytoplasmic protein Nck1) (NCK adapter protein 1) (Nck-1)
Gene: NCK1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030971 - receptor tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 938 Mm			1 377
+	Mm
		223012 CBLB_MOUSE (1-938): 0: 902: 94.20		NCK2_MOUSE (1-376): 3.34e-90: 278: 67.19
+	Hs
		557678 CBLB_HUMAN (1-938): 0: 875: 88.91		NCK1_HUMAN (1-377): 2.9e-97: 295: 98.94
+	Hs
		209046 CBLB_HUMAN (1-938): 0: 875: 88.91		NCK2_HUMAN (1-376): 7.37e-90: 277: 68.50
+	Rn
		1144046 CBLB_RAT (1-938): 0: 919: 98.40		FYN_RAT (6-130): 2.99e-22: 100: 21.26
+	Mm
		1112081 CBLB_MOUSE (1-938): 0: 902: 94.20		ITSN2_MOUSE (3-287): 2.25e-27: 116: 15.17
+	Mm
		82735 B9EKI5_MOUSE (1-938): 0: 926: 100.00		GRB2_MOUSE (3-58): 7.7e-17: 80.6: 28.57
+	Mm
		782847 CBLB_MOUSE (1-938): 0: 902: 94.20		CSK_MOUSE (4-143): 8.51e-17: 83.3: 14.38
+	Mm
		1112053 CBLB_MOUSE (1-938): 0: 902: 94.20		GRB2_MOUSE (3-58): 7.7e-17: 80.6: 28.57
+	Hs
		298976 CBLB_HUMAN (1-938): 0: 875: 88.91		SRBS2_HUMAN (49-287): 4.41e-23: 103: 16.74
+	Hs
		433339 CBLB_HUMAN (1-938): 0: 875: 88.91		YES_HUMAN (6-152): 2.64e-22: 100: 19.87
+	Hs
		655351 CBLB_HUMAN (1-938): 0: 875: 88.91		P85A_HUMAN (241-376): 2.35e-22: 100: 19.57
+	Hs
		412170 CBLB_HUMAN (1-938): 0: 875: 88.91		FYN_HUMAN (6-130): 3.47e-22: 99.8: 21.26
+	Mm
		1112072 CBLB_MOUSE (1-938): 0: 902: 94.20		GRAP_MOUSE (2-60): 2.91e-13: 70.1: 20.34
+	Hs
		129289 CBLB_HUMAN (1-938): 0: 875: 88.91		P85B_HUMAN (252-376): 9.28e-20: 92.9: 24.41
+	Hs
		522956 CBLB_HUMAN (1-938): 0: 875: 88.91		SRC_HUMAN (6-130): 5.78e-19: 90.1: 21.26
+	Hs
		924539 CBLB_HUMAN (1-938): 0: 875: 88.91		GRB2_HUMAN (3-58): 7.33e-17: 80.6: 28.57
+	Hs
		1027606 CBLB_HUMAN (1-938): 0: 875: 88.91		ITSN1_HUMAN (1-127): 4.93e-15: 78.8: 15.75
+	Hs
		1027621 CBLB_HUMAN (1-938): 0: 875: 88.91		SH3K1_HUMAN (6-79): 2.48e-14: 76.2: 19.74
+	Hs
		1027629 CBLB_HUMAN (1-938): 0: 875: 88.91		VAV3_HUMAN (6-60): 5.05e-14: 75.6: 25.00
+	Hs
		1027627 CBLB_HUMAN (1-938): 0: 875: 88.91		ITSN2_HUMAN (7-62): 2.96e-12: 70.2: 30.36