HitPredict

Interactor 1: B9EKJ1 (B9EKJ1)
Spna2 protein
Gene: Sptan1

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27507650, 28671696
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2477 Mm			1 1730
+	Mm
		561160 SPTN1_MOUSE (1-2477): 0: 699: 99.68		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Rn
		555260 SPTN1_RAT (1-2477): 0: 699: 99.31		SHAN3_RAT (1-1730): 0: 618: 98.39
+	Hs
		1045505 SPTN1_HUMAN (1-2477): 0: 699: 98.10		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Hs
		862037 SPTN1_HUMAN (1-2477): 0: 699: 98.10		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Mm
		82740 B9EKJ1_MOUSE (1-2477): 0: 705: 100.00		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Hs
		1021399 SPTN1_HUMAN (1-2477): 0: 699: 98.10		ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01
+	Mm
		1115949 Q68FG2_MOUSE (11-1617): 4.27e-60: 232: 19.86		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		965102 SPTN1_HUMAN (1-2477): 0: 699: 98.10		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Mm
		1115941 SPTB2_MOUSE (1-1050): 2.4e-34: 147: 20.39		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		1045573 SPTN1_HUMAN (1-2477): 0: 699: 98.10		SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37
+	Mm
		561172 SPTN1_MOUSE (1-2477): 0: 699: 99.68		ANK2_MOUSE (134-335): 6.85e-09: 63.5: 31.19
+	Hs
		360612 SPTA1_HUMAN (2-2477): 2.22e-153: 534: 54.60		ANK1_HUMAN (175-669): 2.17e-43: 176: 15.35
+	Mm
		103598 Q3UGX2_MOUSE (446-2157): 1.75e-63: 243: 20.31		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Hs
		862098 CP250_HUMAN (5-1034): 4.57e-34: 147: 9.98		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Hs
		862027 SPTB2_HUMAN (1-1050): 4.55e-34: 146: 20.21		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Mm
		103603 SPTB2_MOUSE (1-1050): 2.4e-34: 147: 20.39		ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58
+	Rn
		251022 PLEC_RAT (1-1353): 8.73e-42: 172: 10.10		ANK3_RAT (12-592): 2.73e-71: 268: 14.49
+	Dr
		1186355 Q7SYE2_DANRE (1985-2475): 7.39e-74: 269: 33.47		MIB1_DANRE (129-324): 1.65e-14: 81.6: 32.50
+	Hs
		1206041 CP250_HUMAN (5-1034): 4.57e-34: 147: 9.98		MIB1_HUMAN (187-625): 7.14e-50: 195: 10.66
+	Hs
		556695 SPTB2_HUMAN (1-1050): 4.55e-34: 146: 20.21		ANK1_HUMAN (175-669): 2.17e-43: 176: 15.35