HitPredict

Interactor 1: AMPH (P49418)
Amphiphysin
Gene: AMPH

Interactor 2: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.755

Property	Details
Experiments	9341169, 9348539, 9280305, 9148966, 29357276, 11877424, 15834155, 17244534, 10542231
Identification Methods	pull down, affinity chromatography technology, peptide array, surface plasmon resonance, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 695 Hs			1 864
+	Mm
		760459 AMPH_MOUSE (1-695): 5.33e-119: 373: 82.90		DYN1_MOUSE (1-845): 0: 1081: 99.65
+	Rn
		139973 AMPH_RAT (1-695): 6.91e-115: 362: 84.75		DYN1_RAT (1-864): 0: 1081: 98.03
+	Hs
		827729 AMPH_HUMAN (1-695): 5.58e-133: 409: 100.00		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		827766 AMPH_HUMAN (1-695): 5.58e-133: 409: 100.00		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Mm
		760477 AMPH_MOUSE (1-695): 5.33e-119: 373: 82.90		DYN2_MOUSE (1-860): 0: 1022: 79.13
+	Mm
		1186718 AMPH_MOUSE (1-695): 5.33e-119: 373: 82.90		DYN3_MOUSE (1-860): 0: 1012: 78.55
+	Rn
		139974 AMPH_RAT (1-695): 6.91e-115: 362: 84.75		DYN2_RAT (1-860): 0: 1021: 79.02
+	Hs
		983387 DNMBP_HUMAN (12-536): 5.06e-55: 206: 18.97		DYN1_HUMAN (1-864): 0: 1087: 100.00
+	Hs
		840739 DNMBP_HUMAN (12-536): 5.06e-55: 206: 18.97		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		131238 BIN1_HUMAN (375-694): 1.37e-32: 135: 23.44		DYN1_HUMAN (1-864): 0: 1087: 100.00
+	Mm
		139028 BIN1_MOUSE (372-695): 1.35e-34: 141: 23.15		DYN1_MOUSE (1-845): 0: 1081: 99.65
+	Rn
		139987 BIN1_RAT (372-695): 8.26e-34: 139: 23.15		DYN1_RAT (1-864): 0: 1081: 98.03
+	Hs
		1167839 DNMBP_HUMAN (12-536): 5.06e-55: 206: 18.97		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Mm
		139029 BIN1_MOUSE (372-695): 1.35e-34: 141: 23.15		DYN2_MOUSE (1-860): 0: 1022: 79.13
+	Hs
		983422 CABIN_HUMAN (291-589): 2.25e-12: 72.8: 12.87		DYN1_HUMAN (1-864): 0: 1087: 100.00
+	Hs
		131222 BIN1_HUMAN (375-694): 1.37e-32: 135: 23.44		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Mm
		139042 BIN1_MOUSE (372-695): 1.35e-34: 141: 23.15		DYN3_MOUSE (1-860): 0: 1012: 78.55
+	Ce
		105220 G5ECK4_CAEEL (12-625): 5.15e-33: 138: 15.04		DYN1_CAEEL (3-805): 0: 916: 64.18
+	Sc
		599466 RV167_YEAST (11-424): 3.83e-41: 158: 15.63		VPS1_YEAST (7-623): 0: 620: 38.38