HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: MSH6 (P52701)
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 1360
+	Hs
		855452 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		MSH6_HUMAN (1-1360): 0: 1486: 100.00
+	Hs
		111558 K7EK07_HUMAN (5-133): 2.58e-51: 161: 49.23		MSH6_HUMAN (1-1360): 0: 1486: 100.00
+	Hs
		855454 H33_HUMAN (5-134): 1.57e-51: 161: 49.62		MSH6_HUMAN (1-1360): 0: 1486: 100.00
+	Hs
		594175 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		MSH3_HUMAN (173-1357): 0: 835: 22.16
+	Hs
		594184 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		MSH3_HUMAN (173-1357): 0: 835: 22.16
+	Hs
		594185 H33_HUMAN (5-134): 1.57e-51: 161: 49.62		MSH3_HUMAN (173-1357): 0: 835: 22.16
+	Hs
		794232 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		MSH2_HUMAN (393-1360): 0: 824: 21.88
+	Hs
		794234 H33_HUMAN (5-134): 1.57e-51: 161: 49.62		MSH2_HUMAN (393-1360): 0: 824: 21.88
+	Sc
		902039 H3_YEAST (5-134): 5.26e-46: 147: 46.57		MSH6_YEAST (115-1347): 0: 821: 28.54
+	Sc
		639281 H3_YEAST (5-134): 5.26e-46: 147: 46.57		MSH2_YEAST (408-1354): 0: 725: 20.96
+	Hs
		828367 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51
+	Hs
		935205 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51
+	Hs
		1086307 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51
+	Hs
		1157224 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51
+	Hs
		952607 H33_HUMAN (5-134): 1.57e-51: 161: 49.62		NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51
+	Hs
		331748 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44
+	Hs
		331780 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44
+	Hs
		331823 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44
+	Hs
		331787 H33_HUMAN (5-134): 1.57e-51: 161: 49.62		NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44
+	Hs
		331833 H32_HUMAN (5-134): 1.73e-51: 161: 48.86		NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44