HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	15009096, 24530302
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	Histone~Histone
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 136
+	Hs
		828187 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		934639 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		828262 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		934660 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		934814 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		934913 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		952367 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		952274 H33_HUMAN (5-134): 1.57e-51: 161: 49.62		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		952429 H32_HUMAN (5-134): 1.73e-51: 161: 48.86		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1086190 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Dm
		356063 H3_DROME (5-134): 1.73e-51: 161: 48.86		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Hs
		934862 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		952391 H33_HUMAN (5-134): 1.57e-51: 161: 49.62		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		828170 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76