HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 793
+	Hs
		935151 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		UHRF1_HUMAN (1-793): 0: 893: 100.00
+	Hs
		935136 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		UHRF2_HUMAN (1-793): 0: 774: 53.01
+	At
		886462 H33_ARATH (5-134): 3.87e-52: 163: 51.15		SUVH4_ARATH (382-642): 2.2e-60: 217: 28.21
+	Hs
		935016 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD5_HUMAN (233-502): 9.75e-55: 207: 18.61
+	Hs
		1086233 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		CHD5_HUMAN (233-502): 9.75e-55: 207: 18.61
+	Hs
		828213 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90
+	Hs
		934705 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90
+	Hs
		934770 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		1059646 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		1059677 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		828415 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		BAZ2A_HUMAN (138-417): 1.39e-38: 157: 17.87
+	Hs
		935347 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		BAZ2A_HUMAN (138-417): 1.39e-38: 157: 17.87
+	Hs
		935339 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KDM5B_HUMAN (227-383): 6.15e-32: 136: 20.35
+	Hs
		666522 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KDM5A_HUMAN (274-383): 9.75e-20: 97.2: 27.27
+	At
		886465 H33_ARATH (5-134): 3.87e-52: 163: 51.15		ATXR5_ARATH (278-414): 1.32e-20: 96.5: 19.74
+	Hs
		666535 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		KDM5A_HUMAN (274-383): 9.75e-20: 97.2: 27.27
+	Hs
		935064 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		DPF3_HUMAN (310-374): 1.48e-18: 90.3: 37.88
+	Hs
		1157213 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		DPF3_HUMAN (310-374): 1.48e-18: 90.3: 37.88
+	At
		886470 H33_ARATH (5-134): 3.87e-52: 163: 51.15		ATXR6_ARATH (292-416): 2.87e-18: 89.1: 26.32
+	Hs
		152625 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		KMT2D_HUMAN (313-363): 2.86e-11: 69.9: 48.08