HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: HELLS (Q9NRZ9)
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
Gene: HELLS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0000775 - chromosome, centromeric region GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005721 - pericentric heterochromatin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 838
+	Hs
		935281 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		HELLS_HUMAN (1-838): 0: 763: 100.00
+	Hs
		828410 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD7_HUMAN (31-836): 0: 657: 27.28
+	Hs
		935324 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD7_HUMAN (31-836): 0: 657: 27.28
+	Hs
		828213 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		934705 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		935262 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD8_HUMAN (2-836): 0: 635: 26.71
+	Hs
		846921 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		828310 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD6_HUMAN (7-836): 0: 623: 26.56
+	Hs
		934770 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Hs
		935016 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD5_HUMAN (50-835): 0: 627: 24.83
+	Hs
		935014 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD6_HUMAN (7-836): 0: 623: 26.56
+	Hs
		229341 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		229359 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Mm
		935460 H31_MOUSE (5-134): 1.29e-52: 164: 48.86		SMCA5_MOUSE (102-833): 0: 605: 31.21
+	Hs
		658641 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA1_HUMAN (104-833): 0: 596: 31.06
+	Hs
		658647 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA1_HUMAN (104-833): 0: 596: 31.06
+	Hs
		828175 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		846743 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		934936 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD1L_HUMAN (218-755): 1.8e-105: 347: 40.30
+	Hs
		935234 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMRCD_HUMAN (206-744): 1.53e-92: 315: 37.59