HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	19410544, 20080577
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 456
+	Hs
		828425 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		935386 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1174695 H32_HUMAN (5-134): 1.73e-51: 161: 48.86		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		730910 CENPA_YEAST (24-134): 1.24e-44: 147: 45.54		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		902040 H3_YEAST (5-134): 5.26e-46: 147: 46.57		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		730956 CENPA_YEAST (24-134): 1.24e-44: 147: 45.54		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Sc
		902155 H3_YEAST (5-134): 5.26e-46: 147: 46.57		RUVB2_YEAST (5-455): 0: 627: 41.72