HitPredict

Interactor 1: UBE2A (P49459)
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Gene: UBE2A

Interactor 2: RNF4 (P78317)
E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)
Gene: RNF4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	27678051
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070936 - protein K48-linked ubiquitination GO:0070979 - protein K11-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 190
+	Hs
		941604 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		849306 UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		919705 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Zm
		39810 B4FCQ9_MAIZE (5-149): 1.72e-78: 230: 39.31		A0A1D6N2L7_MAIZE (13-183): 1.52e-27: 105: 13.98
+	Hs
		919748 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		BRE1A_HUMAN (23-190): 2.03e-24: 101: 19.89
+	Hs
		919747 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		RN220_HUMAN (70-190): 5.19e-23: 97.1: 23.14
+	Sc
		549834 UBC4_YEAST (1-149): 1.43e-77: 228: 36.91		PEX10_YEAST (80-185): 2.25e-23: 96.7: 20.37
+	Hs
		1160856 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		RFWD3_HUMAN (15-189): 1.45e-21: 93.2: 15.85
+	Dm
		639396 UBCD1_DROME (5-149): 2.91e-77: 227: 38.62		Q8I0J6_DROME (32-190): 1.08e-23: 97.1: 30.44
+	Hs
		849343 UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00		RFWD3_HUMAN (15-189): 1.45e-21: 93.2: 15.85
+	Hs
		919753 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		RFWD3_HUMAN (15-189): 1.45e-21: 93.2: 15.85
+	Dm
		639398 UBCD1_DROME (5-149): 2.91e-77: 227: 38.62		Q8IR26_DROME (106-189): 1.2e-21: 90.9: 26.44
+	Hs
		1292368 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34
+	Hs
		849409 UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00		RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34
+	Hs
		919826 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		RN185_HUMAN (126-189): 2.47e-20: 85.5: 31.34
+	Hs
		849377 UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00		COP1_HUMAN (125-189): 3.88e-12: 65.8: 32.31
+	Hs
		919794 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		COP1_HUMAN (125-189): 3.88e-12: 65.8: 32.31
+	At
		715141 UBC9_ARATH (5-149): 1.11e-77: 228: 41.38		Q9LN67_ARATH (130-189): 1.73e-12: 65.4: 31.75
+	Hs
		584907 UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00		RO52_HUMAN (120-187): 1.12e-11: 64.3: 34.78
+	Hs
		584923 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		RO52_HUMAN (120-187): 1.12e-11: 64.3: 34.78