HitPredict

Interactor 1: UBE2A (P49459)
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Gene: UBE2A

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 497
+	Hs
		957802 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		919707 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		919722 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		919818 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		RSPRY_HUMAN (203-493): 4e-56: 198: 14.71
+	Hs
		919721 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		919817 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		BIRC7_HUMAN (14-155): 1.47e-36: 138: 21.83
+	Hs
		1298970 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		BIRC8_HUMAN (160-264): 3.74e-31: 122: 30.48
+	Hs
		919831 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		BIRC8_HUMAN (160-264): 3.74e-31: 122: 30.48
+	At
		715121 UBC8_ARATH (5-149): 3.75e-78: 230: 40.69		RGLG3_ARATH (313-495): 8.04e-27: 113: 16.39
+	Hs
		1165227 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		1316184 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		RNF26_HUMAN (320-496): 6.59e-25: 108: 14.13
+	At
		715118 UBC8_ARATH (5-149): 3.75e-78: 230: 40.69		LUL3_ARATH (335-494): 1.15e-24: 107: 19.41
+	Hs
		919756 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		1264347 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		MYLIP_HUMAN (430-496): 3.78e-23: 103: 35.82
+	Hs
		919803 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		MYLIP_HUMAN (430-496): 3.78e-23: 103: 35.82
+	Hs
		919809 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		RNF34_HUMAN (440-497): 1.43e-18: 89.2: 37.93
+	Hs
		919804 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		RFFL_HUMAN (446-497): 3.49e-18: 88: 44.23
+	Hs
		1206094 UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		919776 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		919813 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		MIB2_HUMAN (437-496): 2e-10: 65.3: 35.00