HitPredict

Interactor 1: UBE2A (P49459)
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Gene: UBE2A

Interactor 2: UBR3 (Q6ZT12)
E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650)
Gene: UBR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.658

Property	Details
Experiments	25582440, 19549727, 21816346
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 152 Hs			1 1888
+	Hs
		919760 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		UBR3_HUMAN (1-1888): 0: 2348: 100.00
+	Hs
		927760 UBE2B_HUMAN (1-151): 3.28e-74: 219: 96.03		UBR3_HUMAN (1-1888): 0: 2348: 100.00
+	Hs
		919780 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		UBR2_HUMAN (1161-1873): 0: 645: 22.71
+	Hs
		829028 UBE2A_HUMAN (1-152): 3.88e-76: 225: 100.00		UBR2_HUMAN (1161-1873): 0: 645: 22.71
+	Hs
		927763 UBE2B_HUMAN (1-151): 3.28e-74: 219: 96.03		UBR2_HUMAN (1161-1873): 0: 645: 22.71
+	Rn
		89844 UBE2B_RAT (1-151): 3.28e-74: 219: 96.03		D5MTH0_RAT (1161-1874): 0: 627: 20.76
+	Hs
		849365 UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00		UBR1_HUMAN (1177-1872): 1.17e-172: 573: 19.57
+	Hs
		919779 UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62		UBR1_HUMAN (1177-1872): 1.17e-172: 573: 19.57
+	Hs
		829027 UBE2A_HUMAN (1-152): 3.88e-76: 225: 100.00		UBR1_HUMAN (1177-1872): 1.17e-172: 573: 19.57
+	Hs
		927762 UBE2B_HUMAN (1-151): 3.28e-74: 219: 96.03		UBR1_HUMAN (1177-1872): 1.17e-172: 573: 19.57
+	Sc
		410241 UBC2_YEAST (1-150): 2.29e-73: 218: 69.33		UBR2_YEAST (1125-1865): 7.05e-56: 217: 16.47
+	Sc
		410209 UBC2_YEAST (1-150): 2.29e-73: 218: 69.33		UBR1_YEAST (120-351): 3.69e-47: 189: 18.47
+	Ce
		854503 UBC1_CAEEL (1-149): 2.14e-72: 216: 85.91		UBR1_CAEEL (1163-1540): 1.66e-29: 131: 14.58
+	Pf
		1211734 Q8IAW2_PLAF7 (1-150): 7.15e-73: 217: 60.67		Q8I586_PLAF7 (336-601): 1.56e-12: 75.7: 15.79