Interactor 1: SYSC (P49591)
Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)
Gene: SARS1

Interactor 2: SYSC (P49591)
Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)
Gene: SARS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 24095058
Identification Methods x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Seryl_tRNA_N~Seryl_tRNA_N, Seryl_tRNA_N~tRNA-synt_2b, tRNA-synt_2b~tRNA-synt_2b
Common GO terms GO:0000049 - tRNA binding
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001514 - selenocysteine incorporation
GO:0002181 - cytoplasmic translation
and 17 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 514
Hs

1 514
+ Dm
+ Ca
+ Hs
+ Hs
+ Ec
+ Hs
+ Cj
+ Hs
+ Sc
+ Sc
+ Ec
+ Hp
+ Ec
+ Pf

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Last updated: 15 Jul 2024