HitPredict

Interactor 1: CASP4 (P49662)
Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
Gene: CASP4

Interactor 2: IL18 (Q14116)
Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
Gene: IL18

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	12096920, 9121587, 15326478
Identification Methods	enzymatic study, protease assay
Interaction Type	direct interaction, cleavage reaction, protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005829 - cytosol GO:0006954 - inflammatory response GO:0050729 - positive regulation of inflammatory response GO:0050830 - defense response to Gram-positive bacterium
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 193
+	Hs
		667465 CASP1_HUMAN (1-377): 1.26e-154: 442: 48.40		IL18_HUMAN (1-193): 3.83e-117: 331: 100.00
+	Hs
		851074 CASP5_HUMAN (3-377): 4.28e-150: 432: 73.60		IL18_HUMAN (1-193): 3.83e-117: 331: 100.00
+	Hs
		788197 CASP3_HUMAN (123-374): 1.79e-91: 277: 26.42		IL18_HUMAN (1-193): 3.83e-117: 331: 100.00