HitPredict

Interactor 1: KC1E (P49674)
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
Gene: CSNK1E

Interactor 2: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32707033, 23455922
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 334
+	Hs
		821966 KC1A_HUMAN (2-326): 1.03e-134: 391: 69.54		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		822233 KC1D_HUMAN (1-406): 2e-125: 370: 83.25		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		1038897 KCC2B_HUMAN (4-396): 1.37e-118: 361: 16.91		WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10
+	Mm
		1206794 KC1A_MOUSE (2-326): 1.03e-134: 391: 69.54		FBXW7_MOUSE (198-333): 2.14e-28: 117: 30.15
+	Hs
		822121 KC1A_HUMAN (2-326): 1.03e-134: 391: 69.54		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		1236899 KC1AL_HUMAN (2-325): 1.08e-129: 378: 66.05		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		681967 AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		196975 KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00		PRP4_HUMAN (244-333): 1.12e-10: 64.2: 19.39
+	Dm
		1213409 AKT1_DROME (1-356): 5.01e-119: 361: 16.76		NLE_DROME (247-333): 4.06e-17: 83.9: 22.99