HitPredict

Interactor 1: KC1E (P49674)
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
Gene: CSNK1E

Interactor 2: GAPD1 (Q14C86)
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)
Gene: GAPVD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	26496610, 28514442, 33961781, 35271311, 32707033, 36736316
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006897 - endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 1478
+	Hs
		822018 KC1A_HUMAN (2-326): 1.03e-134: 391: 69.54		GAPD1_HUMAN (1-1478): 0: 2079: 100.00
+	Hs
		1061935 KC1AL_HUMAN (2-325): 1.08e-129: 378: 66.05		GAPD1_HUMAN (1-1478): 0: 2079: 100.00
+	Hs
		822264 KC1D_HUMAN (1-406): 2e-125: 370: 83.25		GAPD1_HUMAN (1-1478): 0: 2079: 100.00
+	Hs
		809299 KCC2G_HUMAN (4-411): 4.92e-119: 359: 16.31		IQGA1_HUMAN (6-515): 6.57e-125: 429: 15.09
+	Hs
		681732 AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56		IQGA1_HUMAN (6-515): 6.57e-125: 429: 15.09
+	Hs
		822051 KC1A_HUMAN (2-326): 1.03e-134: 391: 69.54		DAB2P_HUMAN (62-602): 5.14e-111: 382: 16.72
+	Hs
		681896 AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56		DAB2P_HUMAN (62-602): 5.14e-111: 382: 16.72
+	Hs
		830500 KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00		NGAP_HUMAN (69-628): 8.13e-78: 283: 14.24
+	Hs
		822192 KC1A_HUMAN (2-326): 1.03e-134: 391: 69.54		NGAP_HUMAN (69-628): 8.13e-78: 283: 14.24
+	Hs
		822398 KC1D_HUMAN (1-406): 2e-125: 370: 83.25		NGAP_HUMAN (69-628): 8.13e-78: 283: 14.24
+	Mm
		99917 KCC2B_MOUSE (4-396): 1.78e-120: 362: 16.91		SYGP1_MOUSE (72-447): 6.74e-73: 270: 15.26
+	Hs
		1038915 KCC2B_HUMAN (4-396): 1.37e-118: 361: 16.91		SYGP1_HUMAN (72-507): 6.42e-73: 270: 15.00
+	Hs
		1039019 KCC2G_HUMAN (4-411): 4.92e-119: 359: 16.31		SYGP1_HUMAN (72-507): 6.42e-73: 270: 15.00
+	Hs
		1039152 KCC2D_HUMAN (4-339): 1.58e-119: 358: 16.62		SYGP1_HUMAN (72-507): 6.42e-73: 270: 15.00
+	Hs
		598472 KCC2B_HUMAN (4-396): 1.37e-118: 361: 16.91		NF1_HUMAN (144-468): 2.57e-58: 225: 18.26
+	Hs
		598473 KCC2G_HUMAN (4-411): 4.92e-119: 359: 16.31		NF1_HUMAN (144-468): 2.57e-58: 225: 18.26
+	Hs
		598474 KCC2D_HUMAN (4-339): 1.58e-119: 358: 16.62		NF1_HUMAN (144-468): 2.57e-58: 225: 18.26
+	Hs
		598432 AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56		NF1_HUMAN (144-468): 2.57e-58: 225: 18.26
+	Hs
		81561 B7Z2B0_HUMAN (4-373): 1.98e-121: 364: 16.18		RIN3_HUMAN (1208-1475): 5.18e-48: 189: 17.69
+	Sc
		580891 HRR25_YEAST (1-298): 3.87e-118: 354: 65.77		IRA2_YEAST (139-358): 6.28e-14: 79.8: 20.81