HitPredict

Interactor 1: NU145 (P49687)
Nucleoporin NUP145 (EC 3.4.21.-) (Nuclear pore protein NUP145) [Cleaved into: Nucleoporin NUP145N (N-NUP145); Nucleoporin NUP145C (C-NUP145)]
Gene: NUP145

Interactor 2: SEC13 (Q04491)
Protein transport protein SEC13
Gene: SEC13

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	25745173, 19576787, 19805193, 11283351, 20512149, 11805826, 9305650, 16554755, 16429126, 15741174, 18046452, 18974315, 37968396, 18046405, 22480613, 19855394, 18160040, 27194810, 21784248
Identification Methods	molecular sieving, pull down, two hybrid pooling approach, cosedimentation in solution, tandem affinity purification, affinity chromatography technology, x-ray crystallography, biochemical, two hybrid array, two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Nup96~WD40
Common GO terms	GO:0005643 - nuclear pore GO:0006606 - protein import into nucleus GO:0031080 - nuclear pore outer ring GO:0045893 - positive regulation of DNA-templated transcription GO:0051664 - nuclear pore localization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1317 Sc			1 297
+	Sc
		830669 NU145_YEAST (1-1317): 0: 1125: 100.00		SEH1_YEAST (1-293): 1.56e-68: 218: 21.97
+	Hs
		903152 IF4G1_HUMAN (3-740): 5.58e-52: 203: 7.92		WDR5_HUMAN (2-237): 1.8e-52: 176: 22.69
+	Hs
		858034 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		SEH1_HUMAN (4-293): 9.65e-93: 280: 28.04
+	Hs
		834655 NU153_HUMAN (16-447): 4.54e-11: 70: 10.50		SEH1_HUMAN (4-293): 9.65e-93: 280: 28.04
+	Hs
		727302 NU214_HUMAN (14-341): 6.71e-11: 69.6: 16.43		SEH1_HUMAN (4-293): 9.65e-93: 280: 28.04
+	Sc
		971875 NU100_YEAST (45-542): 1.84e-14: 80.8: 14.10		SEC13_YEAST (1-297): 1.93e-83: 254: 100.00
+	Sc
		541924 NSP1_YEAST (3-459): 5.33e-11: 69.3: 13.35		SEC13_YEAST (1-297): 1.93e-83: 254: 100.00
+	Sp
		1013470 NU189_SCHPO (54-501): 1.44e-12: 74.7: 11.74		SEH1_SCHPO (2-293): 7.23e-79: 244: 23.35
+	Sc
		858396 NU100_YEAST (45-542): 1.84e-14: 80.8: 14.10		SEH1_YEAST (1-293): 1.56e-68: 218: 21.97
+	Sc
		541905 NSP1_YEAST (3-459): 5.33e-11: 69.3: 13.35		SEH1_YEAST (1-293): 1.56e-68: 218: 21.97
+	Sc
		822983 NUP57_YEAST (118-368): 1.26e-10: 67.7: 15.33		SEH1_YEAST (1-293): 1.56e-68: 218: 21.97
+	Dm
		1358850 NUP98_DROME (2-690): 2.53e-16: 87: 11.42		WDS_DROME (2-238): 1.15e-53: 180: 21.76
+	Hs
		903374 KMT2C_HUMAN (2-484): 1.69e-14: 81.2: 9.36		WDR5_HUMAN (2-237): 1.8e-52: 176: 22.69
+	Hs
		857957 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		WDR5_HUMAN (2-237): 1.8e-52: 176: 22.69
+	Mm
		903669 KMT2C_MOUSE (111-546): 9.34e-13: 75.5: 8.48		WDR5_MOUSE (2-237): 1.8e-52: 176: 22.69
+	Tt
		101901 NU145_CHATD (7-472): 2.07e-10: 67.8: 12.30		SEC13_CHATD (1-234): 2.13e-39: 141: 18.90
+	Sp
		292982 NU189_SCHPO (54-501): 1.44e-12: 74.7: 11.74		SEC13_SCHPO (1-234): 6.63e-36: 132: 20.00
+	Hs
		857954 NUP98_HUMAN (1-435): 2.24e-14: 80.9: 13.29		SEC13_HUMAN (3-104): 2.32e-09: 59.3: 25.46
+	Hs
		297852 SC24D_HUMAN (4-257): 1.65e-12: 74.3: 11.97		SEC13_HUMAN (3-104): 2.32e-09: 59.3: 25.46
+	Hs
		867085 SC24C_HUMAN (2-178): 3.19e-11: 70.1: 12.64		SEC13_HUMAN (3-104): 2.32e-09: 59.3: 25.46