HitPredict

Interactor 1: PSB3 (P49720)
Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)
Gene: PSMB3

Interactor 2: PSMA8 (Q8TAA3)
Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
Gene: PSMA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 256
+	Hs
		656629 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSMA8_HUMAN (1-238): 1.86e-105: 307: 100.00
+	Hs
		156251 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91
+	Hs
		156232 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91
+	Hs
		156228 PSB8_HUMAN (8-205): 2.05e-67: 209: 22.73		PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91
+	Dm
		611632 PSB1_DROME (2-205): 3.62e-70: 215: 26.51		PSA71_DROME (1-237): 2.13e-94: 279: 69.20
+	Hs
		656173 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		PSA5_HUMAN (3-240): 2.51e-91: 271: 36.74
+	Hs
		831968 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		PSA6_HUMAN (2-243): 1.76e-91: 271: 29.27
+	Dm
		771408 PSB1_DROME (2-205): 3.62e-70: 215: 26.51		PSA5_DROME (3-241): 1.12e-91: 272: 35.89
+	Hs
		656151 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSA5_HUMAN (3-240): 2.51e-91: 271: 36.74
+	Hs
		656580 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSA6_HUMAN (2-243): 1.76e-91: 271: 29.27
+	Hs
		637359 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Hs
		638085 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		PSA4_HUMAN (1-237): 2.99e-89: 266: 34.84
+	Hs
		637327 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Hs
		638069 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSA4_HUMAN (1-237): 2.99e-89: 266: 34.84
+	Ss
		94705 G3DRF8_PIG (7-200): 1.52e-69: 213: 22.17		F2Z5L7_PIG (3-249): 1.17e-89: 267: 31.08
+	Hs
		637323 PSB8_HUMAN (8-205): 2.05e-67: 209: 22.73		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Dm
		771285 PSB1_DROME (2-205): 3.62e-70: 215: 26.51		PSA2_DROME (4-222): 1.8e-47: 159: 40.27
+	Hs
		637648 PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51
+	Hs
		637633 PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51
+	Hs
		637629 PSB8_HUMAN (8-205): 2.05e-67: 209: 22.73		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51