HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: ORC2 (Q13416)
Origin recognition complex subunit 2
Gene: ORC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	12614612, 15232106
Identification Methods	two hybrid, affinity chromatography technology, pull down, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003688 - DNA replication origin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005664 - nuclear origin of replication recognition complex and 1 others more... GO:0006270 - DNA replication initiation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 904 Hs			1 577
+	Hs
		708435 MCM4_HUMAN (2-885): 0: 847: 28.42		ORC2_HUMAN (1-577): 0: 797: 100.00
+	Hs
		708628 MCM5_HUMAN (169-902): 0: 768: 29.43		ORC2_HUMAN (1-577): 0: 797: 100.00
+	Hs
		627255 MCM3_HUMAN (186-897): 0: 725: 29.20		ORC2_HUMAN (1-577): 0: 797: 100.00
+	Hs
		1033450 MCM8_HUMAN (119-856): 0: 721: 28.81		ORC2_HUMAN (1-577): 0: 797: 100.00
+	Hs
		1033413 MCM6_HUMAN (186-817): 0: 710: 31.18		ORC2_HUMAN (1-577): 0: 797: 100.00
+	Hs
		708889 MCM7_HUMAN (188-886): 0: 707: 27.35		ORC2_HUMAN (1-577): 0: 797: 100.00
+	Sc
		667558 MCM2_YEAST (11-821): 0: 819: 46.70		ORC2_YEAST (76-571): 7.85e-174: 507: 21.96
+	Sc
		667842 MCM5_YEAST (170-875): 0: 723: 28.23		ORC2_YEAST (76-571): 7.85e-174: 507: 21.96