HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: MCM6 (Q14566)
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
Gene: MCM6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 26496610, 27173435, 17296731, 12694531, 12614612, 12207017, 25416956, 16189514, 25963833, 30100344, 10567526, 33961781, 35235311, 37071682, 26167883, 20211142
Identification Methods affinity chromatography technology, pull down, two hybrid, biochemical, cross-linking study, anti tag coimmunoprecipitation, validated two hybrid, two hybrid array, tandem affinity purification, two hybrid prey pooling approach and 2 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM6_C, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM6_C~MCM_lid, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 8 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 904
Hs

1 821
+ Xl
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Xl
+ Xl
+ Xl
+ At
+ Ce
+ Dm
+ Dm
+ Sp
+ Dm
+ Sp
+ Xl
+ Sp

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Last updated: 15 Jul 2024