HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H2B1H (Q93079)
Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)
Gene: H2BC9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25963833
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 126
+	Hs
		617935 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1O_HUMAN (1-126): 2.36e-55: 170: 99.21
+	Hs
		832512 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B2F_HUMAN (1-126): 1.7e-55: 170: 99.21
+	Hs
		420814 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1J_HUMAN (1-126): 7.3e-55: 169: 97.62
+	Hs
		832497 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		832673 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1M_HUMAN (1-126): 3.95e-55: 169: 96.03
+	Hs
		241476 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		707553 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		832322 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		832280 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1D_HUMAN (1-126): 3.03e-54: 167: 98.41
+	Hs
		832671 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1N_HUMAN (1-126): 3.07e-54: 167: 98.41
+	Hs
		832674 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1L_HUMAN (1-126): 2.43e-53: 165: 97.62
+	Hs
		832577 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B3B_HUMAN (1-126): 1.45e-52: 163: 96.03
+	Hs
		832629 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1A_HUMAN (1-126): 1.15e-47: 151: 84.25
+	Hs
		708456 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		241460 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		707531 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		708414 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		708493 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1A_HUMAN (1-126): 1.15e-47: 151: 84.25
+	Sc
		355815 MCM2_YEAST (11-821): 0: 819: 46.70		H2B2_YEAST (3-125): 4.15e-41: 134: 71.55
+	Sc
		355382 MCM2_YEAST (11-821): 0: 819: 46.70		H2B1_YEAST (4-125): 8.17e-37: 123: 72.13