HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H2B1A (Q96A08)
Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)
Gene: H2BC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	25963833, 26186194, 28514442, 33961781, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly and 1 others more... GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 127
+	Hs
		832673 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1M_HUMAN (1-127): 6.74e-55: 169: 84.25
+	Hs
		832512 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B2F_HUMAN (5-127): 1.83e-54: 168: 85.37
+	Hs
		420814 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1J_HUMAN (1-127): 4.39e-54: 167: 85.04
+	Hs
		617935 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1O_HUMAN (5-127): 3.41e-54: 167: 86.18
+	Hs
		832497 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		241476 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1K_HUMAN (1-127): 8.56e-54: 166: 84.25
+	Hs
		707553 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		832280 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1D_HUMAN (1-127): 1.37e-53: 166: 85.04
+	Hs
		832322 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		832624 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1H_HUMAN (5-127): 5.52e-54: 166: 85.37
+	Hs
		832671 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1N_HUMAN (1-127): 1.22e-53: 166: 85.83
+	Hs
		832674 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1L_HUMAN (1-127): 1.35e-52: 163: 85.83
+	Hs
		832577 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B3B_HUMAN (1-127): 8.98e-51: 158: 85.83
+	Hs
		708456 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		241460 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1K_HUMAN (1-127): 8.56e-54: 166: 84.25
+	Hs
		707531 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		708414 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		708493 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1A_HUMAN (1-127): 1.72e-52: 163: 100.00
+	Sc
		355815 MCM2_YEAST (11-821): 0: 819: 46.70		H2B2_YEAST (4-126): 4.46e-41: 134: 69.36
+	Hs
		241461 MCM5_HUMAN (169-902): 0: 768: 29.43		H2B1K_HUMAN (1-127): 8.56e-54: 166: 84.25