HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: SLD5 (Q9BRT9)
DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]
Gene: GINS4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	27592030, 22374673, 30392930, 33961781, 34195792
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	MCM~Sld5, MCM_N~Sld5
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006268 - DNA unwinding involved in DNA replication and 1 others more... GO:0071162 - CMG complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 904 Hs			1 223
+	Mm
		956197 MCM2_MOUSE (1-904): 0: 1058: 95.58		SLD5_MOUSE (1-223): 2.1e-91: 269: 87.89
+	Dm
		832227 MCM2_DROME (32-902): 0: 965: 64.83		Q9VBI1_DROME (19-223): 9.24e-68: 209: 39.51
+	Hs
		708503 MCM4_HUMAN (2-885): 0: 847: 28.42		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Hs
		708751 MCM5_HUMAN (169-902): 0: 768: 29.43		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Sc
		667627 MCM2_YEAST (11-821): 0: 819: 46.70		SLD5_YEAST (14-223): 2.88e-67: 210: 20.97
+	Dm
		1099472 MCM4_DROME (2-869): 0: 803: 26.19		Q9VBI1_DROME (19-223): 9.24e-68: 209: 39.51
+	Mm
		627416 MCM3_MOUSE (186-897): 0: 725: 28.80		SLD5_MOUSE (1-223): 2.1e-91: 269: 87.89
+	Hs
		627346 MCM3_HUMAN (186-897): 0: 725: 29.20		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Mm
		956209 MCM6_MOUSE (186-817): 0: 713: 30.88		SLD5_MOUSE (1-223): 2.1e-91: 269: 87.89
+	Hs
		1055616 MCM6_HUMAN (186-817): 0: 710: 31.18		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Mm
		1143182 MCM7_MOUSE (188-886): 0: 706: 27.61		SLD5_MOUSE (1-223): 2.1e-91: 269: 87.89
+	Sc
		675553 MCM4_YEAST (7-889): 0: 764: 25.82		SLD5_YEAST (14-223): 2.88e-67: 210: 20.97
+	Hs
		709029 MCM7_HUMAN (188-886): 0: 707: 27.35		SLD5_HUMAN (1-223): 5.17e-90: 265: 100.00
+	Dm
		1361990 MCM5_DROME (195-902): 0: 745: 30.39		Q9VBI1_DROME (19-223): 9.24e-68: 209: 39.51
+	Sc
		667884 MCM5_YEAST (170-875): 0: 723: 28.23		SLD5_YEAST (14-223): 2.88e-67: 210: 20.97
+	Dm
		1362003 MCM3_DROME (187-884): 0: 710: 31.08		Q9VBI1_DROME (19-223): 9.24e-68: 209: 39.51