HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 372
+	Hs
		555351 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		832655 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1A_HUMAN (1-128): 1.35e-65: 206: 60.31
+	Hs
		708532 MCM4_HUMAN (2-885): 0: 847: 28.42		H2AW_HUMAN (1-372): 5.27e-152: 434: 100.00
+	Hs
		832567 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A2B_HUMAN (1-123): 1.24e-64: 203: 63.49
+	Hs
		832623 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1C_HUMAN (1-126): 2.96e-64: 202: 61.24
+	Hs
		832672 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1J_HUMAN (1-125): 2.23e-64: 202: 60.94
+	Hs
		391599 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		470300 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1_HUMAN (1-126): 6.37e-64: 201: 60.47
+	Hs
		594831 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1D_HUMAN (1-126): 1.13e-63: 201: 60.47
+	Hs
		832496 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A2C_HUMAN (1-126): 7.57e-64: 201: 61.24
+	Hs
		832523 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A2A_HUMAN (1-126): 4.27e-64: 201: 62.02
+	Hs
		832548 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A3_HUMAN (1-126): 5.3e-64: 201: 61.24
+	Hs
		832648 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1H_HUMAN (1-125): 5.02e-64: 201: 60.94
+	Hs
		832683 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2AJ_HUMAN (1-126): 1.06e-63: 201: 60.47
+	Hs
		555318 MCM4_HUMAN (2-885): 0: 847: 28.42		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		391569 MCM4_HUMAN (2-885): 0: 847: 28.42		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		708464 MCM4_HUMAN (2-885): 0: 847: 28.42		H2A2A_HUMAN (1-126): 4.27e-64: 201: 62.02
+	Hs
		391570 MCM5_HUMAN (169-902): 0: 768: 29.43		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Sc
		392073 MCM2_YEAST (11-821): 0: 819: 46.70		H2A1_YEAST (14-125): 3.15e-41: 143: 65.79
+	Sc
		392333 MCM2_YEAST (11-821): 0: 819: 46.70		H2A2_YEAST (14-124): 2.55e-41: 143: 65.77