HitPredict

Interactor 1: VPS41 (P49754)
Vacuolar protein sorting-associated protein 41 homolog (S53)
Gene: VPS41

Interactor 2: PKHM1 (Q9Y4G2)
Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)
Gene: PLEKHM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.681

Property	Details
Experiments	25500191, 28325809, 33452816
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005764 - lysosome GO:0031902 - late endosome membrane GO:0046872 - metal ion binding GO:1902774 - late endosome to lysosome transport
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 854 Hs			1 1056
+	Hs
		1350055 VPS18_HUMAN (281-827): 8.87e-114: 372: 13.32		PKHM1_HUMAN (1-1056): 0: 1398: 100.00
+	Hs
		1329152 VPS11_HUMAN (344-854): 1.68e-97: 327: 18.51		PKHM1_HUMAN (1-1056): 0: 1398: 100.00
+	Hs
		1295100 VPS39_HUMAN (340-824): 4.36e-79: 275: 17.43		PKHM1_HUMAN (1-1056): 0: 1398: 100.00
+	Hs
		960938 CLH1_HUMAN (368-774): 2.71e-50: 194: 13.78		RUFY1_HUMAN (13-506): 8.59e-67: 240: 18.15