HitPredict

Interactor 1: RBM25 (P49756)
RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)
Gene: RBM25

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006397 - mRNA processing and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 843 Hs			1 551
+	Hs
		833476 RBM25_HUMAN (1-843): 8.68e-63: 229: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		1084551 PHF3_HUMAN (280-432): 6.42e-20: 98.1: 25.33		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084613 CSTFT_HUMAN (76-170): 1.7e-15: 82.5: 29.17		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		703389 CSTF2_HUMAN (78-259): 3.07e-15: 81.8: 16.84		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084649 ITSN2_HUMAN (3-678): 5.19e-14: 78.7: 10.77		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Dm
		1364315 Q9VE52_DROME (75-197): 1.55e-18: 91: 30.95		CPSF6_DROME (8-485): 1.09e-43: 166: 36.97
+	Hs
		302292 GRDN_HUMAN (116-772): 9.29e-12: 71.4: 11.87		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		703436 CSTF2_HUMAN (78-259): 3.07e-15: 81.8: 16.84		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69