HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~PID
Common GO terms	GO:0005886 - plasma membrane GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Hs			1 1824
+	Hs
		297818 K0754_HUMAN (163-529): 9.31e-23: 106: 12.00		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		833595 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		833625 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		LNX2_HUMAN (908-1089): 8.99e-18: 91.8: 18.13
+	Mm
		1265184 NUMB_MOUSE (1-651): 8.07e-101: 323: 92.96		LNX2_MOUSE (973-1126): 6.83e-17: 88.9: 20.38
+	Hs
		957180 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Mm
		1143409 Q8BZM2_MOUSE (7-213): 4.14e-51: 185: 18.75		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		1143393 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		1066808 CHD7_HUMAN (166-648): 1.27e-09: 63.7: 9.26		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		1066964 PCLO_HUMAN (228-583): 5.04e-09: 62: 20.06		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Rn
		677795 M3K11_RAT (347-644): 1.91e-39: 157: 18.05		DLG4_RAT (1002-1238): 9.23e-28: 123: 17.51
+	Mm
		1143503 CAPON_MOUSE (8-274): 2.77e-39: 153: 17.75		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		887083 ANS1A_MOUSE (8-244): 6.92e-38: 153: 18.91		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		140100 NUMBL_MOUSE (1-651): 3.53e-45: 171: 46.48		LNX2_MOUSE (973-1126): 6.83e-17: 88.9: 20.38
+	Dm
		113386 Q9VCM6_DROME (16-171): 3.96e-36: 148: 20.38		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95
+	Mm
		957153 DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49		PARD3_MOUSE (937-1811): 1.22e-20: 101: 11.59
+	Dm
		113280 CAPON_DROME (28-247): 1.95e-34: 141: 19.83		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95
+	Hs
		253559 CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Mm
		88458 D3Z656_MOUSE (143-634): 1.08e-10: 67.2: 10.60		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Mm
		1143433 SYNJ1_MOUSE (146-613): 1.78e-10: 66.4: 10.25		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Dm
		113146 DAB_DROME (37-172): 1.47e-11: 70.1: 29.71		M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95