HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	34079125, 35271311, 23211419
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Hs			1 937
+	Hs
		833587 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Rn
		923852 Q3MUI1_RAT (1-651): 2.15e-78: 262: 83.13		AP2B1_RAT (1-937): 0: 926: 100.00
+	Hs
		925893 ARH_HUMAN (4-293): 1.38e-52: 185: 19.67		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		926067 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		925962 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		1014028 ARH_HUMAN (4-293): 1.38e-52: 185: 19.67		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		253551 CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		925851 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		321513 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		302120 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Ce
		283753 CED6_CAEEL (7-402): 5.6e-36: 143: 14.85		Q9N4F3_CAEEL (1-935): 0: 770: 62.11
+	Rn
		577194 Q3MUI1_RAT (1-651): 2.15e-78: 262: 83.13		AP2A2_RAT (11-932): 0: 595: 16.50
+	Rn
		1109842 Q3MUI1_RAT (1-651): 2.15e-78: 262: 83.13		Q66HM2_RAT (11-932): 0: 590: 16.38
+	Mm
		567529 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		AP2A2_MOUSE (11-932): 0: 596: 16.50
+	Hs
		321528 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		302137 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Dm
		561275 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		AP2A_DROME (11-931): 0: 573: 16.72
+	Ce
		60777 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q8WQB3_CAEEL (14-643): 1.28e-151: 470: 15.54
+	Ce
		60774 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q22601_CAEEL (9-626): 7.54e-140: 442: 20.26
+	Ce
		283751 CED6_CAEEL (7-402): 5.6e-36: 143: 14.85		Q22601_CAEEL (9-626): 7.54e-140: 442: 20.26