HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: LNX1 (Q8TBB1)
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
Gene: LNX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	11782429, 29121065, 14990566, 16002321
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PDZ~PID
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 651 Hs			1 728
+	Mm
		250665 NUMB_MOUSE (1-651): 8.07e-101: 323: 92.96		LNX1_MOUSE (1-728): 8.14e-134: 414: 87.98
+	Hs
		833625 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		LNX2_HUMAN (3-728): 5.7e-116: 366: 45.21
+	Mm
		1265184 NUMB_MOUSE (1-651): 8.07e-101: 323: 92.96		LNX2_MOUSE (1-728): 4.94e-115: 364: 45.62
+	Hs
		1252574 NUMBL_HUMAN (1-651): 4.19e-48: 180: 45.55		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		1115807 Q49AR9_HUMAN (8-267): 1.14e-40: 158: 17.80		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		1252371 ANS1A_HUMAN (8-244): 1.9e-39: 158: 18.49		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		269170 DAB1_HUMAN (31-622): 1.27e-34: 141: 15.66		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Mm
		140100 NUMBL_MOUSE (1-651): 3.53e-45: 171: 46.48		LNX2_MOUSE (1-728): 4.94e-115: 364: 45.62
+	Hs
		833631 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		PARD3_HUMAN (247-554): 1.39e-32: 137: 20.96
+	Mm
		1143409 Q8BZM2_MOUSE (7-213): 4.14e-51: 185: 18.75		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Mm
		1143393 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Mm
		957153 DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49		PARD3_MOUSE (204-552): 1.48e-32: 137: 18.61
+	Rn
		957050 Q3MUI2_RAT (1-651): 1.76e-49: 184: 44.70		GRIP1_RAT (507-720): 1.63e-12: 73.2: 28.84
+	Rn
		677795 M3K11_RAT (347-644): 1.91e-39: 157: 18.05		DLG4_RAT (267-582): 6.83e-21: 99.8: 16.09
+	Mm
		1143503 CAPON_MOUSE (8-274): 2.77e-39: 153: 17.75		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Mm
		887083 ANS1A_MOUSE (8-244): 6.92e-38: 153: 18.91		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Hs
		253559 CAPON_HUMAN (8-286): 2.51e-35: 141: 17.11		SCRIB_HUMAN (265-624): 2.64e-15: 82.4: 13.52
+	Mm
		88458 D3Z656_MOUSE (143-634): 1.08e-10: 67.2: 10.60		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Mm
		1143433 SYNJ1_MOUSE (146-613): 1.78e-10: 66.4: 10.25		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40