HitPredict

Interactor 1: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	23211419
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0045296 - cadherin binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 651 Hs			1 864
+	Hs
		787868 NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		788008 NUMB_MOUSE (1-651): 8.07e-101: 323: 92.96		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Mm
		1141842 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		EP15R_MOUSE (1-862): 1.06e-124: 399: 92.11
+	Mm
		957141 DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49		EP15R_MOUSE (1-862): 1.06e-124: 399: 92.11
+	Hs
		787894 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		787999 DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Rn
		1126747 SYNJ1_RAT (313-650): 6.99e-09: 61.4: 11.77		Q5JC29_RAT (1-782): 2.53e-93: 313: 42.20
+	Mm
		1206702 ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75		ITSN1_MOUSE (2-556): 1.43e-30: 132: 13.55
+	Ce
		1353620 NUMB1_CAEEL (1-539): 6.75e-43: 165: 28.52		Q9U2T9_CAEEL (119-652): 4.86e-35: 146: 17.92
+	Ce
		60780 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q9U2T9_CAEEL (119-652): 4.86e-35: 146: 17.92
+	Ce
		283754 CED6_CAEEL (7-402): 5.6e-36: 143: 14.85		Q9U2T9_CAEEL (119-652): 4.86e-35: 146: 17.92
+	Dm
		112569 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		M9ND00_DROME (1-488): 3.53e-29: 127: 12.91
+	Hs
		269148 DAB1_HUMAN (31-622): 1.27e-34: 141: 15.66		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Mm
		957157 DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49		ITSN1_MOUSE (2-556): 1.43e-30: 132: 13.55
+	Hs
		957186 DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Dm
		561284 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		Q8T8W3_DROME (126-214): 1.79e-18: 92: 50.56
+	Ce
		60778 A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32		Q8WSP1_CAEEL (118-220): 7.82e-21: 99.8: 53.33
+	Dm
		91154 NUMB_DROME (16-540): 1.63e-40: 157: 36.14		E3CTP7_DROME (504-831): 1.9e-12: 73.2: 8.54