HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.80	0.801

Property	Details
Experiments	12890497, 32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 484 Hs			1 164
+	Hs
		833742 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		833720 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		833727 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		266940 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		833721 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Hs
		833728 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		992944 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		1028829 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		267075 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		625466 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		993837 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Hs
		1029103 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		833865 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00
+	Hs
		833870 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		266941 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		516362 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		516416 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		625590 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		RBM4_HUMAN (11-88): 3.45e-18: 81.9: 28.21
+	Hs
		833871 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Hs
		833875 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44