HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.80	0.714

Property	Details
Experiments	26167880, 33961781
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 484 Hs			1 272
+	Hs
		833720 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		833721 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		833728 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		992944 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		1028829 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		993837 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		1029103 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		833870 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		833871 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		834026 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		834031 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		834027 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		833875 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		833711 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		625590 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		RBM4_HUMAN (3-122): 5.32e-17: 81.7: 22.50
+	Hs
		516362 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		516416 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		516417 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		833865 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		834022 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56