HitPredict

Interactor 1: CLK1 (P49759)
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
Gene: CLK1

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.897

Property	Details
Experiments	26167880, 32296183, 33961781, unassigned1304
Identification Methods	enzymatic study, two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 484 Hs			1 238
+	Hs
		833788 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60
+	Hs
		833711 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		833720 CLK1_HUMAN (1-484): 7.43e-162: 468: 100.00		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		992944 CLK4_HUMAN (1-482): 5.96e-145: 425: 78.31		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		625466 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		833887 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		833938 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60
+	Hs
		432550 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		834053 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		432604 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		833865 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		432605 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		833870 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		516362 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		834022 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		516416 CLK2_HUMAN (1-481): 1.89e-133: 396: 53.83		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		834033 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		PABP4_HUMAN (1-95): 5.76e-21: 92.9: 27.00
+	Hs
		834026 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		516417 CLK3_HUMAN (1-480): 2.72e-128: 388: 49.49		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		625590 CDK2_HUMAN (158-484): 4.73e-137: 398: 25.45		RBM4_HUMAN (12-89): 4.44e-14: 72.2: 33.33