HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: TRA2A (Q13595)
Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)
Gene: TRA2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	26186194, 28514442, 33961781, 32707033, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 638 Hs			1 282
+	Hs
		516417 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77
+	Hs
		834033 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13
+	Hs
		834017 CLK3_HUMAN (1-638): 0: 542: 100.00		TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30
+	Hs
		833731 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00
+	Hs
		625415 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00
+	Hs
		833877 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00
+	Hs
		516362 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77
+	Hs
		516416 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77
+	Hs
		1040325 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00
+	Hs
		833706 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30
+	Hs
		833857 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30
+	Dm
		580161 DOA_DROME (36-635): 2.7e-120: 378: 37.52		TRA2_DROME (97-281): 1.36e-44: 153: 43.78
+	Hs
		1031320 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13
+	Hs
		516508 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77
+	Hs
		1040371 DYRK2_HUMAN (93-633): 2.19e-117: 364: 23.45		TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00
+	Hs
		925032 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30
+	Hs
		201668 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		MSI1H_HUMAN (100-255): 8.46e-26: 106: 22.22
+	Hs
		1043781 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		CIRBP_HUMAN (121-193): 2.19e-10: 60.1: 58.90
+	At
		621700 CDKA1_ARATH (301-623): 2.57e-123: 368: 23.33		RB45A_ARATH (108-275): 1.01e-12: 69.4: 15.64