HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 559
+	Hs
		834041 CLK3_HUMAN (1-638): 0: 542: 100.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		625633 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00
+	Hs
		834030 CLK3_HUMAN (1-638): 0: 542: 100.00		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		834096 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		833736 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		833880 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1043792 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		834033 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		516417 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		625400 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		833874 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		833945 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		1020254 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		642764 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		ELAV4_HUMAN (16-210): 6.97e-20: 93.7: 16.92
+	Hs
		516362 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		516416 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		1044050 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		CELF6_HUMAN (213-307): 4.94e-14: 76.4: 23.47
+	Hs
		1031320 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		516508 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Dm
		834204 DOA_DROME (36-635): 2.7e-120: 378: 37.52		Q9VM49_DROME (130-203): 2.05e-11: 68.6: 43.24