HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: GPTC8 (Q9UKJ3)
G patch domain-containing protein 8
Gene: GPATCH8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	28514442, 33961781, 32707033, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 638 Hs			1 1502
+	Hs
		833989 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		GPTC8_HUMAN (1-1502): 0: 787: 100.00
+	Hs
		625176 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		MYH9_HUMAN (93-1004): 5.83e-88: 320: 10.29
+	Ce
		246633 MBK2_CAEEL (286-625): 2.98e-48: 183: 32.96		O61201_CAEEL (188-1450): 2.26e-128: 446: 11.27
+	Hs
		625177 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		MYH10_HUMAN (93-975): 5.18e-52: 204: 9.51
+	Hs
		151409 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		CHD1_HUMAN (400-987): 2.47e-56: 218: 13.45
+	Hs
		725159 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		MYH10_HUMAN (93-975): 5.18e-52: 204: 9.51
+	Hs
		1043978 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		THOC2_HUMAN (580-1024): 3.56e-35: 149: 15.03
+	Hs
		833803 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		MINT_HUMAN (344-1427): 5.09e-09: 63.7: 10.39
+	Hs
		625425 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		EIF3A_HUMAN (648-1008): 2.86e-09: 64.3: 15.18
+	Hs
		960129 CDK3_HUMAN (301-632): 2.49e-129: 384: 23.89		MYH13_HUMAN (89-1074): 4e-11: 70.2: 8.64
+	Hs
		522604 CDK3_HUMAN (301-632): 2.49e-129: 384: 23.89		MYH7_HUMAN (89-963): 5.28e-11: 69.9: 8.95