HitPredict

Interactor 1: DOA (P49762)
Serine/threonine-protein kinase Doa (EC 2.7.12.1) (Protein darkener of apricot)
Gene: DOA

Interactor 2: Q9V3T8 (Q9V3T8)
LD32469p (SR family splicing factor SC35) (SR family splicing factor SC35, isoform C) (SR family splicing factor SC35, isoform D)
Gene: SC35

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15575970
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 832 Dm			1 195
+	Dm
		834168 DOA_DROME (1-817): 0: 643: 100.00		Q7KTD2_DROME (84-195): 1.08e-36: 125: 100.00
+	Hs
		266942 CLK3_HUMAN (190-815): 1.1e-135: 419: 38.99		SRS10_HUMAN (23-172): 1.02e-26: 104: 37.01
+	Hs
		834109 CLK3_HUMAN (190-815): 1.1e-135: 419: 38.99		SRSF8_HUMAN (10-107): 1.2e-26: 104: 67.35
+	Hs
		834033 CLK3_HUMAN (190-815): 1.1e-135: 419: 38.99		PABP4_HUMAN (14-111): 5.48e-25: 103: 28.57
+	Hs
		516417 CLK3_HUMAN (190-815): 1.1e-135: 419: 38.99		PABP1_HUMAN (14-111): 9.34e-25: 102: 28.57
+	Hs
		516362 CDK2_HUMAN (476-811): 2.68e-140: 418: 24.20		PABP1_HUMAN (14-111): 9.34e-25: 102: 28.57
+	Hs
		266941 CLK2_HUMAN (370-818): 1.7e-131: 403: 56.14		SRS10_HUMAN (23-172): 1.02e-26: 104: 37.01
+	Hs
		833957 CLK2_HUMAN (370-818): 1.7e-131: 403: 56.14		SRSF8_HUMAN (10-107): 1.2e-26: 104: 67.35
+	Hs
		266940 CLK1_HUMAN (335-800): 5.63e-131: 401: 46.25		SRS10_HUMAN (23-172): 1.02e-26: 104: 37.01
+	Hs
		516416 CLK2_HUMAN (370-818): 1.7e-131: 403: 56.14		PABP1_HUMAN (14-111): 9.34e-25: 102: 28.57
+	Hs
		833805 CLK1_HUMAN (335-800): 5.63e-131: 401: 46.25		SRSF8_HUMAN (10-107): 1.2e-26: 104: 67.35
+	Hs
		267075 CLK4_HUMAN (327-800): 6.03e-129: 396: 46.96		SRS10_HUMAN (23-172): 1.02e-26: 104: 37.01
+	At
		847172 AFC2_ARATH (379-803): 2.21e-130: 398: 40.32		SRC33_ARATH (22-187): 3.83e-25: 100: 37.64
+	Hs
		834087 CLK3_HUMAN (190-815): 1.1e-135: 419: 38.99		SRS12_HUMAN (24-114): 6.02e-10: 58.9: 46.15
+	Hs
		267037 DYRK2_HUMAN (375-820): 2.26e-114: 362: 24.18		SRS10_HUMAN (23-172): 1.02e-26: 104: 37.01
+	Hs
		833938 CLK2_HUMAN (370-818): 1.7e-131: 403: 56.14		SRS12_HUMAN (24-114): 6.02e-10: 58.9: 46.15
+	Hs
		833788 CLK1_HUMAN (335-800): 5.63e-131: 401: 46.25		SRS12_HUMAN (24-114): 6.02e-10: 58.9: 46.15