HitPredict - High confidence protein-protein interactions

Interactor 1: PSN1 (P49769)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: Psen1

Interactor 2: NICA (P57716)
Nicastrin
Gene: Ncstn

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15474363, 16641999, 22036569
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005765 - lysosomal membrane GO:0005769 - early endosome GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane and 25 others more... GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0006509 - membrane protein ectodomain proteolysis GO:0007219 - Notch signaling pathway GO:0007220 - Notch receptor processing GO:0007611 - learning or memory GO:0008021 - synaptic vesicle GO:0008233 - peptidase activity GO:0016020 - membrane GO:0016485 - protein processing GO:0021549 - cerebellum development GO:0032991 - protein-containing complex GO:0034205 - amyloid-beta formation GO:0042383 - sarcolemma GO:0042734 - presynaptic membrane GO:0042982 - amyloid precursor protein metabolic process GO:0042987 - amyloid precursor protein catabolic process GO:0043085 - positive regulation of catalytic activity GO:0050435 - amyloid-beta metabolic process GO:0050673 - epithelial cell proliferation GO:0051117 - ATPase binding GO:0051402 - neuron apoptotic process GO:0070765 - gamma-secretase complex GO:0070851 - growth factor receptor binding GO:0097060 - synaptic membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	467
Mm

1	708

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Last updated: 15 Jul 2024