HitPredict

Interactor 1: RBP2 (P49792)
E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)
Gene: RANBP2

Interactor 2: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	33961781, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006607 - NLS-bearing protein import into nucleus and 2 others more... GO:0016020 - membrane GO:0031965 - nuclear membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 3224 Hs			1 529
+	Hs
		134854 RBP2_HUMAN (1-3224): 0: 2967: 100.00		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		131404 RBP2_HUMAN (1-3224): 0: 2967: 100.00		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		834694 RBP2_HUMAN (1-3224): 0: 2967: 100.00		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		853521 PPIE_HUMAN (2962-3223): 8.74e-99: 323: 38.95		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		152769 RGPD8_HUMAN (2355-3064): 2.79e-42: 174: 17.03		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		853440 RGPD5_HUMAN (2355-3076): 9.38e-42: 172: 16.89		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		134921 RGPD4_HUMAN (2358-3076): 2.55e-42: 174: 17.14		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		63862 RGPD3_HUMAN (2313-3076): 6.96e-42: 172: 16.92		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Dm
		853807 NU153_DROME (1294-1955): 2.11e-30: 135: 17.80		IMA_DROME (6-529): 2.4e-121: 368: 48.30