HitPredict

Interactor 1: PSN2 (P49810)
Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
Gene: PSEN2

Interactor 2: NICA (Q92542)
Nicastrin
Gene: NCSTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 0.60 0.650

The method score is based on:

Property Details
Experiments 12297508, 10993067, 15474363
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000139 - Golgi membrane
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
and 14 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 448
Hs

1 709
+ Mm
+ Hs
+ Rn
+ Mm
+ Dm
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024