Interactor 1: PSN2 (P49810)
Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
Gene: PSEN2

Interactor 2: APH1A (Q96BI3)
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)
Gene: APH1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.839

The method score is based on:

Property Details
Experiments 12471034, 12297508, 15474363
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Aph-1~Presenilin
Common GO terms GO:0000139 - Golgi membrane
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
and 12 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 448
Hs

1 265
+ Mm
+ Hs
+ Hs
+ Mm
+ Rn
+ Mm
+ Hs
+ At
+ Dm
+ At

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Last updated: 15 Jul 2024